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2023 Vol.33, Issue 11 Preview Page

Research Paper

Extracted Catechin Incorporated Chitosan Patch for Dermal Drug Delivery Systems
Seunghwan Choy1†
1Digital Health Research Division, Korea Institute of Oriental Medicine (KIOM), Daejeon 34054, Republic of Korea
†Corresponding author E-Mail : schoy@kiom.re.kr (S. Choy, KIOM)
27 November 2023. pp. 458-464
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Abstract

In order to develop catechin patches for skin regeneration at wound sites, patches with varying concentrations of catechin and chitosan were manufactured. An optimal composition ratio was determined by adjusting the drug release rate and amount, to maximize efficiency. The catechin used in this study was extracted from green tea leaves using a solvent/ultrasonication method, and its characteristics were confirmed through Fourier transform-infrared spectroscopy (FT-IR) and high-performance liquid chromatography (HPLC) analyses. Patches were prepared with different concentrations of catechin and chitosan, and various properties were analyzed using techniques such as FT-IR, water contact angle analysis, and UV-Vis spectroscopy. It was observed that as the chitosan concentration increased, the release of catechin slowed down or almost ceased. A patch manufactured with 1.5 mg/cm2 of catechin at a 1 % chitosan concentration exhibited a high initial release rate over 24 h and demonstrated cellular biocompatibility. Consequently, these patches, with tailored release characteristics based on the concentrations of chitosan and catechin, hold promise for use as drug delivery systems in wound healing applications.

Keywords
catechin
chitosan
drug release system
patch
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Information
  • Publisher :Materials Research Society of Korea
  • Publisher(Ko) :한국재료학회
  • Journal Title :Korean Journal of Materials Research
  • Journal Title(Ko) :한국재료학회지
  • Volume : 33
  • No :11
  • Pages :458-464
  • Received Date : 2023-10-24
  • Revised Date : 2023-11-08
  • Accepted Date : 2023-11-10
  • DOI :https://doi.org/10.3740/MRSK.2023.33.11.458
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