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2021 Vol.31, Issue 6 Preview Page

Technical Report

Gentamicin/CTMA/Montmorillonite as Slow-Released Antibacterial Agent
Is Fatimah1†
,
Habibi Hidayat1
,
Gani Purwiandono1
,
Saddam Husein2
,
Won-Chun Oh3
1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Islam Indonesia, Kampus Terpadu UII, Jl. Kaliurang Km 14, Sleman, Yogyakarta, Indonesia
2Laboratory of Materials for Energy and Environemnt, Department of Chemistry, Universitas Islam Indonesia, Kampus Terpadu UII, Jl. Kaliurang Km 14, Sleman, Yogyakarta, Indonesia
3Department of Advanced Materials Science and Engineering, Hanseo University, Seosan-si, Chungnam 356-706, South Korea
†Corresponding author E-Mail : isfatimah@uii.ac.id (I. Fatimah, Univ. Islam Indonesia)
June 2021. pp. 367-374
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Abstract

This paper presents the characteristics of gentamicin-loaded into cetyl trimethyl ammonium intercalated montmorillonite (GtM/CTMA/Mt) as a hybrid composite for a slow-released antibacterial delivery systems. The work describes the successful immobilization of gentamicin into the interlayers of surfactant-modified montmorillonite. Physicochemical characterization of the material is carried out by means of X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and Fourier transform infrared spectroscopy. The kinetics of the gentamicin release is investigated by in vitro study and analyzed based on UV–Vis spectrometry. In addition, antibacterial study is performed towards Klebsiella pneumoniae Staphylococcus aureus, Escherichia coli, and Streptococcus pyogenes. The results show that the gentamicin loading into CTMA/ Mt increases the effectiveness of the antibacterial activity, as shown by the higher inhibition zone for all tested bacteria, compared to gentamicin as a positive control. The kinetics study suggests that the gentamicin release obeys the modified Korsmeyer–Peppas model. The physicochemical study and activity test demonstrate the feasibility of the GtM/CTMA/Mt for practical applications.

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Information
  • Publisher :Materials Research Society of Korea
  • Publisher(Ko) :한국재료학회
  • Journal Title :Korean Journal of Materials Research
  • Journal Title(Ko) :한국재료학회지
  • Volume : 31
  • No :6
  • Pages :367-374
  • Received Date : 2021-04-21
  • Revised Date : 2021-04-21
  • Accepted Date : 2021-06-08
  • DOI :https://doi.org/10.3740/MRSK.2021.31.6.367
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