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2021 Vol.31, Issue 5 Preview Page
Electroconductive Graphene-Combined Polycaprolactone Electrospun Films for Biological Applications

생체적 적용을 위한 전기전도성을 갖는 그래핀과 폴리카프로락톤 복합물질 전기방사 섬유형 필름

Jun-Sung Oh
,
Eun-Jung Lee†
오 준성
,
이 은정†
Department of Nano-Biomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Korea
단국대학교 나노바이오의과학과
†Corresponding author E-Mail : leeej@dankook.ac.kr (E.-J. Lee, Dankook Univ.)
May 2021. pp. 278-285
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Abstract

This study produces electroconductive polycaprolactone (PCL)-based film with different amounts of graphene (G) through electrospinning, and the characteristics of the produced G/PCL composites are investigated. The G/PCL results are analyzed by comparing them with those obtained using pure PCL electrospun film as a control. The morphology of electrospun material is analyzed through scanning electron microscopy and transmission electron microscopy. Mechanical and electrical properties are also evaluated. Composites containing 1% graphene have the highest elongation rate, and 5% samples have the highest strength and elasticity. Graphene contents > 25% show electro-conductivity, which level improves with increase of graphene content. Biological characteristics of G/PCL composites are assessed through behavioral analysis of neural cell attachment and proliferation. Cell experiments reveal that compositions < 50% show slightly reduced cell viability. Moreover, graphene combinations facilitated cell proliferation compared to pure PCL. These results confirm that a 25 % G/PCL composition is best for application to systems that introduce external stimuli such as electric fields and electrodes to lead to synergistic efficiency of tissue regeneration.

Keywords
graphene
electroconductive
polycaprolactone
electrospinning
neural cell
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Information
  • Publisher :Materials Research Society of Korea
  • Publisher(Ko) :한국재료학회
  • Journal Title :Korean Journal of Materials Research
  • Journal Title(Ko) :한국재료학회지
  • Volume : 31
  • No :5
  • Pages :278-285
  • Received Date : 2021-03-31
  • Revised Date : 2021-04-23
  • Accepted Date : 2021-04-24
  • DOI :https://doi.org/10.3740/MRSK.2021.31.5.278
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