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2024 Vol.34, Issue 11 Preview Page

Research Paper

Polycaprolactone/Chitosan Composite Film for Bisphosphonates Delivery System
Seunghwan Choy1†
1Digital Health Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea
†Corresponding author E-Mail : schoy@kiom.re.kr (S. Choy, KIOM)
27 November 2024. pp. 552-559
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Abstract

This study investigates the development of risedronate (RSD)-incorporated polycaprolactone (PCL)/chitosan composite films for potential use in drug delivery systems aimed at bone repair. PCL and chitosan were blended in varying ratios (25 %, 50 %, 75 % PCL), and their miscibility, morphology, and hydrophilicity were analyzed. The effects of incorporating RSD at different concentrations (10-7 to 10-4 M) on MG63 preosteoblast cell proliferation and differentiation were also evaluated. The results demonstrated that blending of the hydrophobic PCL with hydrophilic chitosan was challenging, due to poor miscibility and phase separation. Optimal blending conditions and drying temperatures were essential for homogeneous film formation. The incorporation of RSD influenced cellular behavior, with 50 % PCL showing the most effective cell proliferation and moderate hydrophilicity. However, higher RSD concentrations (10-4 M) inhibited proliferation, while lower concentrations (10-7 M) promoted it. RSD also enhanced osteoblast differentiation, as evidenced by increased alkaline phosphatase (ALP) activity, particularly in 75 % PCL films. These findings suggest that adjusting the PCL/chitosan ratio and RSD concentration can optimize drug release and cellular responses, making this composite system a promising candidate for bone tissue engineering applications.

Keywords
chitosan
polycaprolactone
bone repair
risedronate
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Information
  • Publisher :Materials Research Society of Korea
  • Publisher(Ko) :한국재료학회
  • Journal Title :Korean Journal of Materials Research
  • Journal Title(Ko) :한국재료학회지
  • Volume : 34
  • No :11
  • Pages :552-559
  • Received Date : 2024-10-16
  • Revised Date : 2024-10-24
  • Accepted Date : 2024-10-31
  • DOI :https://doi.org/10.3740/MRSK.2024.34.11.552
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